Método:Īnálisis retrospectivo de resultados histológicos y citológicos después de un año de seguimiento desde la captura híbrida para investigación de ADN-VPH de alto riesgo en pacientes con diagnóstico previo de ASC.
Objetivo:Įl objetivo de este estudio es evaluar la capacidad de detección del ADN-VPH de alto riesgo por captura híbrida en predecir lesiones intraepiteliales y cáncer en pacientes con diagnóstico colpocitológico inicial de atipia de células escamosas (ASC). La colpocitología y la investigación del ácido desoxirribonucleico (ADN) del virus del papiloma humano (VPH) de alto riesgo son herramientas bien conocidas para la detección de lesiones cervicales, puesto que permiten el diagnóstico precoz del cáncer y sus lesiones precursoras. Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.Ĭervical squamous cells of the atypia early detection of cancer cervical intraepithelial neoplasia cervical squamous intraepithelial lesions papillomavirus infections Brazil Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Results:Īmong the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions.
Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions.
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